According to the author, Chapel Road "is the book about the childhood of Ondine [...] about her brother Valeer-Traleer with his monstrous head wobbling through life this way and that." But the book is about a lot more than that. It is also the story of Louis Paul Boon, an author working on a novel entitled Chapel Road, surrounded by his colorful group of friends. His readers and companions include the painter Tippetotje, who habitually works a naked woman into her paintings, and Johan Janssens, the journalist and poet who is fired from the paper for refusing to agree with the Capitalists, the Socialists or the Ultra-Marxists.
Beyond that, Chapel Road includes a retelling of the myth of Reynard the fox and Isengrinus the wolf, a tale that underscores the greed, stupidity, hypocrisy, pride and lust motivating the other characters of the book.
Chapel Road is "a pool, a sea, a chaos: it is the book of all that can be heard and seen in Chapel Road, from the year 1800-and-something until today."